DegronMD

Uniprot ID: Q9Y3Z3

Source protein: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Source gene: SAMHD1

Class: LIG_APCC_ABBAyCdc20_2

Location: 617:623

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9956

ASA_SCORE: 96.9

COIL: 0.7229

CONS_SCORE: 0.2377

DSS_SCORE: 0.7583

HELIX: 0.1301

FCONS_SCORE: 1.0449

RIG_SCORE: 0.7499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R611Q	TCGA-AO-A128	BRCA	TCGA	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R611Q	DO5326	BRCA	ICGC	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R611Q	SIDM00845	Burkitt's Lymphoma	GDSC	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R611Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T608A	TCGA-CD-A48C	STAD	TCGA	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.5278
p.T608A	DO47912	STAD	ICGC	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.5278
p.V618L	SIDM01048	Plasma Cell Myeloma	GDSC	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.5654
p.V618L	ACH-000821	Myeloma	CCLE	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.5654
p.V618L	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.5654
p.L620P	ACH-000568	Breast Cancer	CCLE	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.7582
p.D624G	ACH-001786	Colon/Colorectal Cancer	CCLE	RVQLFKD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Z3	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	LIG_APCC_ABBAyCdc20_2	617:623	RVQLFKD	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons