DegronMD

Uniprot ID: Q16526

Source protein: Cryptochrome-1

Source gene: CRY1

Class: DEG_COP1_1

Location: 183:195

E3 ligase: COP1

DEGRON score: 0.9372

ASA_SCORE: 65.2231

COIL: 0.7636

CONS_SCORE: 0.3868

DSS_SCORE: 0.5245

HELIX: 0.1978

FCONS_SCORE: 1.1303

RIG_SCORE: 0.7571

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S194L	TCGA-EE-A2A1	SKCM	TCGA	SDDHDEKYGVPSL	DEG_COP1_1	0.7667
p.S194L	DO38045	SKCM	ICGC	SDDHDEKYGVPSL	DEG_COP1_1	0.7667
p.Y190F	DO23362	LINC	ICGC	SDDHDEKYGVPSL	DEG_COP1_1	0.6417
p.L195V	ACH-001035	Bone Cancer	CCLE	SDDHDEKYGVPSL	DEG_COP1_1	0.5654
p.P181S	TCGA-BT-A42F	BLCA	TCGA	SDDHDEKYGVPSL	DEG_COP1_1	0.2778
p.P181S	TCGA-FW-A3R5	SKCM	TCGA	SDDHDEKYGVPSL	DEG_COP1_1	0.2778
p.P181S	DO49726	BLCA	ICGC	SDDHDEKYGVPSL	DEG_COP1_1	0.2778
p.P181S	DO37406	SKCM	ICGC	SDDHDEKYGVPSL	DEG_COP1_1	0.2778
p.F200C	TCGA-DU-6392	LGG	TCGA	SDDHDEKYGVPSL	DEG_COP1_1	0.1944
p.F200C	DO22237	LGG	ICGC	SDDHDEKYGVPSL	DEG_COP1_1	0.1944
p.C178S	SIDM00523	Small Cell Lung Carcinoma	GDSC	SDDHDEKYGVPSL	DEG_COP1_1	0.1944
p.C178S	ACH-000698	Lung Cancer	CCLE	SDDHDEKYGVPSL	DEG_COP1_1	0.1944
p.C178S	DMS-53	lung	COSMIC	SDDHDEKYGVPSL	DEG_COP1_1	0.1944
p.D201N	TCGA-24-1434	OV	TCGA	SDDHDEKYGVPSL	DEG_COP1_1	0.1667
p.D201N	DO28014	OV	ICGC	SDDHDEKYGVPSL	DEG_COP1_1	0.1667

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16526	Cryptochrome-1	DEG_COP1_1	183:195	SDDHDEKYGVPSL	COP1	0.9372	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons