DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
SDLSLLVPEI
Uniprot ID:
Q9Y4C2
Source protein:
TRPM8 channel-associated factor 1
Source gene:
TCAF1
Class:
DEG_COP1_1
Location:
504:513
E3 ligase:
COP1
DEGRON score:
0.505
ASA_SCORE:
52.06
COIL:
0.7029
CONS_SCORE:
0.3868
DSS_SCORE:
0.2577
HELIX:
0.2061
FCONS_SCORE:
1.1577
RIG_SCORE:
0.78
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TCAF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SDLSLLVPEI
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y4C2
TRPM8 channel-associated factor 1
DEG_COP1_1
504:513
SDLSLLVPEI
COP1
0.505
More...