DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_COP1_1

Location: 1702:1710

E3 ligase: COP1

DEGRON score: 0.9973

ASA_SCORE: 76.3333

COIL: 0.8558

CONS_SCORE: 0.3785

DSS_SCORE: 0.6242

HELIX: 0.0203

FCONS_SCORE: 1.156

RIG_SCORE: 0.666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1710I	TCGA-2F-A9KT	BLCA	TCGA	SDSHVVPSV	DEG_COP1_1	0.5965
p.V1710I	TCGA-CQ-5326	HNSC	TCGA	SDSHVVPSV	DEG_COP1_1	0.5965
p.A1716D	TCGA-AP-A1DV	UCEC	TCGA	SDSHVVPSV	DEG_COP1_1	0.1667
p.H1705N	TCGA-L9-A8F4	LUAD	TCGA	SDSHVVPSV	DEG_COP1_1	0.6312
p.S1704F	TCGA-WE-A8K6	SKCM	TCGA	SDSHVVPSV	DEG_COP1_1	0.6871
p.G1714V	DO228976	LICA	ICGC	SDSHVVPSV	DEG_COP1_1	0.2222
p.S1703P	DO40855	UCEC	ICGC	SDSHVVPSV	DEG_COP1_1	0.6752
p.V1716I	DO41542	UCEC	ICGC	SDSHVVPSV	DEG_COP1_1	0.1667
p.P1694S	DO43891	UCEC	ICGC	SDSHVVPSV	DEG_COP1_1	0.1111
p.R1710Q	DO42753	UCEC	ICGC	SDSHVVPSV	DEG_COP1_1	0.7329
p.V1718A	SIDM00650	Small Cell Lung Carcinoma	GDSC	SDSHVVPSV	DEG_COP1_1	0.1111
p.V1718A	SIDM01681	Non-Cancerous	GDSC	SDSHVVPSV	DEG_COP1_1	0.1111
p.P1720H	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	SDSHVVPSV	DEG_COP1_1	0.0556
p.E1698D	RMG-I	ovary	COSMIC	SDSHVVPSV	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_COP1_1	1702:1710	SDSHVVPSV	COP1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons