DegronMD

Uniprot ID: Q969G3

Source protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

Source gene: SMARCE1

Class: DEG_COP1_1

Location: 204:215

E3 ligase: COP1

DEGRON score: 0.8576

ASA_SCORE: 64.925

COIL: 0.6273

CONS_SCORE: 0.6383

DSS_SCORE: 0.206

HELIX: 0.2648

FCONS_SCORE: 1.0013

RIG_SCORE: 0.7884

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I206L	TCGA-12-0775	GBM	TCGA	SEILSESVVPDV	DEG_COP1_1	0.6063
p.L207F	TCGA-2W-A8YY	CESC	TCGA	SEILSESVVPDV	DEG_COP1_1	0.587
p.Q197H	TCGA-86-7953	LUAD	TCGA	SEILSESVVPDV	DEG_COP1_1	0.1389
p.R201H	TCGA-AO-A128	BRCA	TCGA	SEILSESVVPDV	DEG_COP1_1	0.25
p.R216W	TCGA-AX-A0J0	UCEC	TCGA	SEILSESVVPDV	DEG_COP1_1	0.3056
p.R201C	TCGA-AZ-6598	COAD	TCGA	SEILSESVVPDV	DEG_COP1_1	0.25
p.S217L	TCGA-BH-A0HF	BRCA	TCGA	SEILSESVVPDV	DEG_COP1_1	0.2778
p.V215D	TCGA-CG-4442	STAD	TCGA	SEILSESVVPDV	DEG_COP1_1	0.7785
p.A194T	TCGA-FP-A8CX	STAD	TCGA	SEILSESVVPDV	DEG_COP1_1	0.0556
p.R195S	TCGA-GN-A262	SKCM	TCGA	SEILSESVVPDV	DEG_COP1_1	0.0833
p.E209Q	DO767	BLCA	ICGC	SEILSESVVPDV	DEG_COP1_1	0.5633
p.E209Q	SIDM00983	Bladder Carcinoma	GDSC	SEILSESVVPDV	DEG_COP1_1	0.5633
p.E209Q	ACH-000896	Bladder Cancer	CCLE	SEILSESVVPDV	DEG_COP1_1	0.5633
p.E209Q	647-V	urinary_tract	COSMIC	SEILSESVVPDV	DEG_COP1_1	0.5633
p.S199L	DO1749	BRCA	ICGC	SEILSESVVPDV	DEG_COP1_1	0.1944
p.L210I	DO229027	LICA	ICGC	SEILSESVVPDV	DEG_COP1_1	0.7174
p.V196G	DO229485	SKCA	ICGC	SEILSESVVPDV	DEG_COP1_1	0.1111
p.V197D	DO38380	STAD	ICGC	SEILSESVVPDV	DEG_COP1_1	0.1389
p.L211I	DO41572	UCEC	ICGC	SEILSESVVPDV	DEG_COP1_1	0.7174
p.R216G	SIDM01063	Acute Myeloid Leukemia	GDSC	SEILSESVVPDV	DEG_COP1_1	0.3056
p.V218A	ACH-001719	Ovarian Cancer	CCLE	SEILSESVVPDV	DEG_COP1_1	0.25
p.R198L	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	SEILSESVVPDV	DEG_COP1_1	0.1667
p.R216L	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	SEILSESVVPDV	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969G3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	DEG_COP1_1	204:215	SEILSESVVPDV	COP1	0.8576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons