DegronMD

Uniprot ID: Q86XK7

Source protein: V-set and immunoglobulin domain-containing protein 1

Source gene: VSIG1

Class: DEG_COP1_1

Location: 336:344

E3 ligase: COP1

DEGRON score: 0.8258

ASA_SCORE: 82.6778

COIL: 0.9129

CONS_SCORE: 0.2867

DSS_SCORE: 0.9124

HELIX: 0.0436

FCONS_SCORE: 0.8323

RIG_SCORE: 0.615

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T350A	TCGA-A8-A08A	BRCA	TCGA	SEPMAVPDL	DEG_COP1_1	0.1667
p.T350A	DO2599	BRCA	ICGC	SEPMAVPDL	DEG_COP1_1	0.1667
p.D331Y	TCGA-AX-A05Z	UCEC	TCGA	SEPMAVPDL	DEG_COP1_1	0.1944
p.T346N	TCGA-OR-A5JA	ACC	TCGA	SEPMAVPDL	DEG_COP1_1	0.2778
p.P334R	DO28265	OV	ICGC	SEPMAVPDL	DEG_COP1_1	0.2778
p.L348Q	ACH-000943	Colon/Colorectal Cancer	CCLE	SEPMAVPDL	DEG_COP1_1	0.2222
p.L348Q	RKO	large_intestine	COSMIC	SEPMAVPDL	DEG_COP1_1	0.2222
p.A333D	ACH-001623	Brain Cancer	CCLE	SEPMAVPDL	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XK7	V-set and immunoglobulin domain-containing protein 1	DEG_COP1_1	336:344	SEPMAVPDL	COP1	0.8258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons