DegronMD

Uniprot ID: Q9BXT5

Source protein: Testis-expressed protein 15

Source gene: TEX15

Class: DEG_COP1_1

Location: 1582:1590

E3 ligase: COP1

DEGRON score: 0.7163

ASA_SCORE: 83.3889

COIL: 0.7643

CONS_SCORE: 0.3793

DSS_SCORE: 0.2883

HELIX: 0.1176

FCONS_SCORE: 1.0288

RIG_SCORE: 0.8079

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1579H	TCGA-17-Z030	LUAD	TCGA	SETCKVPTL	DEG_COP1_1	0.25
p.V1598M	TCGA-19-5956	GBM	TCGA	SETCKVPTL	DEG_COP1_1	0.1111
p.V1598M	DO13863	GBM	ICGC	SETCKVPTL	DEG_COP1_1	0.1111
p.V1598M	DO23108	LINC	ICGC	SETCKVPTL	DEG_COP1_1	0.1111
p.V1598M	DO45041	LINC	ICGC	SETCKVPTL	DEG_COP1_1	0.1111
p.L1590I	TCGA-86-8073	LUAD	TCGA	SETCKVPTL	DEG_COP1_1	0.6063
p.L1590I	DO23624	LUAD	ICGC	SETCKVPTL	DEG_COP1_1	0.6063
p.A1580T	TCGA-AA-3811	COAD	TCGA	SETCKVPTL	DEG_COP1_1	0.2778
p.A1580T	TCGA-FI-A2D5	UCEC	TCGA	SETCKVPTL	DEG_COP1_1	0.2778
p.A1580T	DO7962	COAD	ICGC	SETCKVPTL	DEG_COP1_1	0.2778
p.A1580T	DO41331	UCEC	ICGC	SETCKVPTL	DEG_COP1_1	0.2778
p.S1596L	TCGA-AP-A051	UCEC	TCGA	SETCKVPTL	DEG_COP1_1	0.1667
p.S1596L	DO222662	MELA	ICGC	SETCKVPTL	DEG_COP1_1	0.1667
p.S1596L	DO42673	UCEC	ICGC	SETCKVPTL	DEG_COP1_1	0.1667
p.S1596P	TCGA-BR-A4CQ	STAD	TCGA	SETCKVPTL	DEG_COP1_1	0.1667
p.S1596P	DO47861	STAD	ICGC	SETCKVPTL	DEG_COP1_1	0.1667
p.T1575M	TCGA-CM-6674	COAD	TCGA	SETCKVPTL	DEG_COP1_1	0.1389
p.T1575M	TCGA-HC-7745	PRAD	TCGA	SETCKVPTL	DEG_COP1_1	0.1389
p.T1575M	DO10092	COAD	ICGC	SETCKVPTL	DEG_COP1_1	0.1389
p.T1575M	DO49809	PRAD	ICGC	SETCKVPTL	DEG_COP1_1	0.1389
p.T1575M	PC-3_[JPC-3]	lung	COSMIC	SETCKVPTL	DEG_COP1_1	0.1389
p.A1595V	TCGA-F1-A72C	STAD	TCGA	SETCKVPTL	DEG_COP1_1	0.1944
p.A1595V	DO50125	STAD	ICGC	SETCKVPTL	DEG_COP1_1	0.1944
p.V1598L	TCGA-KF-A41W	SARC	TCGA	SETCKVPTL	DEG_COP1_1	0.1111
p.V1598L	DO220199	SARC	ICGC	SETCKVPTL	DEG_COP1_1	0.1111
p.S1580C	SIDM00847	Rhabdomyosarcoma	GDSC	SETCKVPTL	DEG_COP1_1	0.2778
p.S1580C	RD	soft_tissue	COSMIC	SETCKVPTL	DEG_COP1_1	0.2778
p.T1576I	SIDM01617	Endometrial Carcinoma	GDSC	SETCKVPTL	DEG_COP1_1	0.1667
p.H1581R	ACH-000258	Breast Cancer	CCLE	SETCKVPTL	DEG_COP1_1	0.3056
p.H1581R	DU-4475	breast	COSMIC	SETCKVPTL	DEG_COP1_1	0.3056
p.K1593N	ACH-000926	Colon/Colorectal Cancer	CCLE	SETCKVPTL	DEG_COP1_1	0.3611
p.K1593N	HT55	large_intestine	COSMIC	SETCKVPTL	DEG_COP1_1	0.3611
p.H1574R	ACH-002508	Skin Cancer	CCLE	SETCKVPTL	DEG_COP1_1	0.1111
p.N1573D	SW1463	large_intestine	COSMIC	SETCKVPTL	DEG_COP1_1	0.0833
p.S1584C	RD	soft_tissue	COSMIC	SETCKVPTL	DEG_COP1_1	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SETCKVPTL

Degron related mutations and impact score

Drug responses associated with TEX15 mutations

All proteins holding degron of SETCKVPTL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXT5	Testis-expressed protein 15	DEG_COP1_1	1582:1590	SETCKVPTL	COP1	0.7163	More...