DegronMD

Uniprot ID: O75593

Source protein: Forkhead box protein H1

Source gene: FOXH1

Class: DEG_COP1_1

Location: 199:207

E3 ligase: COP1

DEGRON score: 0.9542

ASA_SCORE: 76.4222

COIL: 0.9181

CONS_SCORE: 0.3252

DSS_SCORE: 0.7237

HELIX: 0.0396

FCONS_SCORE: 0.7398

RIG_SCORE: 0.583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A203V	TCGA-FI-A2D5	UCEC	TCGA	SGEEAVPTP	DEG_COP1_1	0.5825
p.A203V	DO41331	UCEC	ICGC	SGEEAVPTP	DEG_COP1_1	0.5825
p.A203V	SIDM01611	Endometrial Carcinoma	GDSC	SGEEAVPTP	DEG_COP1_1	0.5825
p.A203V	ACH-000996	Endometrial/Uterine Cancer	CCLE	SGEEAVPTP	DEG_COP1_1	0.5825
p.L209F	DO220906	MELA	ICGC	SGEEAVPTP	DEG_COP1_1	0.2778
p.L209P	DO219881	SKCA	ICGC	SGEEAVPTP	DEG_COP1_1	0.2778
p.P210L	DO218874	SKCA	ICGC	SGEEAVPTP	DEG_COP1_1	0.25
p.L216Q	DO229250	THCA	ICGC	SGEEAVPTP	DEG_COP1_1	0.0833
p.T196A	ACH-000384	Bladder Cancer	CCLE	SGEEAVPTP	DEG_COP1_1	0.25
p.T196A	SW780	urinary_tract	COSMIC	SGEEAVPTP	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75593	Forkhead box protein H1	DEG_COP1_1	199:207	SGEEAVPTP	COP1	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons