DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
SHPSQPPVPSL
Uniprot ID:
O15117
Source protein:
FYN-binding protein 1
Source gene:
FYB1
Class:
DEG_COP1_1
Location:
409:419
E3 ligase:
COP1
DEGRON score:
0.8122
ASA_SCORE:
86.2
COIL:
0.9619
CONS_SCORE:
0.5255
DSS_SCORE:
0.7982
HELIX:
0.0126
FCONS_SCORE:
0.9757
RIG_SCORE:
0.487
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FYB1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SHPSQPPVPSL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15117
FYN-binding protein 1
DEG_COP1_1
409:419
SHPSQPPVPSL
COP1
0.8122
More...