DegronMD

Uniprot ID: P10909

Source protein: Clusterin

Source gene: CLU

Class: DEG_COP1_1

Location: 391:402

E3 ligase: COP1

DEGRON score: 0.9684

ASA_SCORE: 75.6917

COIL: 0.9172

CONS_SCORE: 0.4453

DSS_SCORE: 0.3365

HELIX: 0.0231

FCONS_SCORE: 0.8233

RIG_SCORE: 0.7101

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R396W	DO41871	UCEC	ICGC	SHTSDSDVPSGV	DEG_COP1_1	0.8634
p.S400F	TCGA-3C-AALI	BRCA	TCGA	SHTSDSDVPSGV	DEG_COP1_1	0.7982
p.D391H	DO20897	KIRP	ICGC	SHTSDSDVPSGV	DEG_COP1_1	0.7688
p.S396L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	SHTSDSDVPSGV	DEG_COP1_1	0.7667
p.S396L	SIDM00690	Head and Neck Carcinoma	GDSC	SHTSDSDVPSGV	DEG_COP1_1	0.7667
p.S396L	SIDM01147	Gastric Carcinoma	GDSC	SHTSDSDVPSGV	DEG_COP1_1	0.7667
p.S396L	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	SHTSDSDVPSGV	DEG_COP1_1	0.7667
p.V398I	TCGA-KQ-A41R	BLCA	TCGA	SHTSDSDVPSGV	DEG_COP1_1	0.7076
p.V400A	DO48009	STAD	ICGC	SHTSDSDVPSGV	DEG_COP1_1	0.6936
p.V402I	SIDM00293	Small Cell Lung Carcinoma	GDSC	SHTSDSDVPSGV	DEG_COP1_1	0.5965
p.V402I	ACH-002052	Lung Cancer	CCLE	SHTSDSDVPSGV	DEG_COP1_1	0.5965
p.V402I	LU-139	lung	COSMIC	SHTSDSDVPSGV	DEG_COP1_1	0.5965
p.E390K	DO7934	COAD	ICGC	SHTSDSDVPSGV	DEG_COP1_1	0.3056
p.E390K	DO229035	LICA	ICGC	SHTSDSDVPSGV	DEG_COP1_1	0.3056
p.V389A	TCGA-CD-A4MG	STAD	TCGA	SHTSDSDVPSGV	DEG_COP1_1	0.2778
p.R385W	TCGA-B5-A3FC	UCEC	TCGA	SHTSDSDVPSGV	DEG_COP1_1	0.1667
p.V409I	DO223592	BLCA	ICGC	SHTSDSDVPSGV	DEG_COP1_1	0.1389
p.Y383N	ACH-000634	Brain Cancer	CCLE	SHTSDSDVPSGV	DEG_COP1_1	0.1111
p.S411F	DO219589	BRCA	ICGC	SHTSDSDVPSGV	DEG_COP1_1	0.0833

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10909	Clusterin	DEG_COP1_1	391:402	SHTSDSDVPSGV	COP1	0.9684	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons