DegronMD

Uniprot ID: Q2M1K9

Source protein: Zinc finger protein 423

Source gene: ZNF423

Class: DEG_Kelch_Keap1_1

Location: 626:631

E3 ligase: KEAP1

DEGRON score: 0.9589

ASA_SCORE: 79.3833

COIL: 0.8473

CONS_SCORE: 0.51

DSS_SCORE: 0.3527

HELIX: 0.0442

FCONS_SCORE: 1.0721

RIG_SCORE: 0.6418

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A624T	TCGA-2W-A8YY	CESC	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.2778
p.A624T	TCGA-AA-3864	COAD	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.2778
p.A624T	TCGA-EO-A22R	UCEC	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.2778
p.A624T	TCGA-F5-6814	READ	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.2778
p.L639F	TCGA-44-3918	LUAD	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.1111
p.A622S	TCGA-55-8511	LUAD	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.2222
p.F641L	TCGA-78-7148	LUAD	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.0556
p.R619Q	TCGA-AX-A0J1	UCEC	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.1389
p.R619Q	SIDM01511	Gastric Carcinoma	GDSC	SISNGE	DEG_Kelch_Keap1_1	0.1389
p.R619Q	ACH-000746	Gastric Cancer	CCLE	SISNGE	DEG_Kelch_Keap1_1	0.1389
p.P633S	TCGA-EE-A2GI	SKCM	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.2778
p.S621L	TCGA-ZF-A9R3	BLCA	TCGA	SISNGE	DEG_Kelch_Keap1_1	0.1944
p.S621L	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	SISNGE	DEG_Kelch_Keap1_1	0.1944
p.S621L	ACH-000447	Lung Cancer	CCLE	SISNGE	DEG_Kelch_Keap1_1	0.1944
p.S621L	NCI-H2228	lung	COSMIC	SISNGE	DEG_Kelch_Keap1_1	0.1944
p.Y632N	DO44071	BLCA	ICGC	SISNGE	DEG_Kelch_Keap1_1	0.3056
p.C637Y	DO227979	COCA	ICGC	SISNGE	DEG_Kelch_Keap1_1	0.1667
p.L621R	DO234187	ESAD	ICGC	SISNGE	DEG_Kelch_Keap1_1	0.1944
p.E635K	DO233807	GACA	ICGC	SISNGE	DEG_Kelch_Keap1_1	0.2222
p.E635K	EC-GI-10	oesophagus	COSMIC	SISNGE	DEG_Kelch_Keap1_1	0.2222
p.E635K	IM-95	stomach	COSMIC	SISNGE	DEG_Kelch_Keap1_1	0.2222
p.D638N	DO223719	LUSC	ICGC	SISNGE	DEG_Kelch_Keap1_1	0.1389
p.D638N	DO38427	STAD	ICGC	SISNGE	DEG_Kelch_Keap1_1	0.1389
p.S629L	DO48547	STAD	ICGC	SISNGE	DEG_Kelch_Keap1_1	0.7667
p.T622S	DO223286	UCEC	ICGC	SISNGE	DEG_Kelch_Keap1_1	0.2222
p.R617Q	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SISNGE	DEG_Kelch_Keap1_1	0.0833
p.E631G	SIDM00217	Colorectal Carcinoma	GDSC	SISNGE	DEG_Kelch_Keap1_1	0.7199
p.E631G	ACH-000999	Colon/Colorectal Cancer	CCLE	SISNGE	DEG_Kelch_Keap1_1	0.7199
p.E631G	SNU-1040	large_intestine	COSMIC	SISNGE	DEG_Kelch_Keap1_1	0.7199
p.E631Q	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	SISNGE	DEG_Kelch_Keap1_1	0.6744
p.E631Q	ACH-000875	Lung Cancer	CCLE	SISNGE	DEG_Kelch_Keap1_1	0.6744
p.E631Q	NCI-H2347	lung	COSMIC	SISNGE	DEG_Kelch_Keap1_1	0.6744
p.A623T	SW684	soft_tissue	COSMIC	SISNGE	DEG_Kelch_Keap1_1	0.25
p.Q619H	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	SISNGE	DEG_Kelch_Keap1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SISNGE

Degron related mutations and impact score

Drug responses associated with ZNF423 mutations

All proteins holding degron of SISNGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M1K9	Zinc finger protein 423	DEG_Kelch_Keap1_1	626:631	SISNGE	KEAP1	0.9589	More...