DegronMD

Uniprot ID: P43246

Source protein: DNA mismatch repair protein Msh2

Source gene: MSH2

Class: DEG_APCC_KENBOX_2

Location: 112:116

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7326

ASA_SCORE: 81.06

COIL: 0.769

CONS_SCORE: 0.2428

DSS_SCORE: 0.2476

HELIX: 0.0768

FCONS_SCORE: 0.729

RIG_SCORE: 0.8022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A107T	TCGA-F7-A624	HNSC	TCGA	SKEND	DEG_APCC_KENBOX_2	0.1944
p.R106T	TCGA-XF-A9SY	BLCA	TCGA	SKEND	DEG_APCC_KENBOX_2	0.1667
p.S102P	DO8224	COAD	ICGC	SKEND	DEG_APCC_KENBOX_2	0.0556
p.I126V	DO8264	COAD	ICGC	SKEND	DEG_APCC_KENBOX_2	0.0556
p.A123S	DO45317	LUAD	ICGC	SKEND	DEG_APCC_KENBOX_2	0.1389
p.E122D	DO45317	LUAD	ICGC	SKEND	DEG_APCC_KENBOX_2	0.2778
p.S119P	DO232043	ORCA	ICGC	SKEND	DEG_APCC_KENBOX_2	0.25
p.C110Y	DO51761	STAD	ICGC	SKEND	DEG_APCC_KENBOX_2	0.2778
p.K106R	DO52402	UCEC	ICGC	SKEND	DEG_APCC_KENBOX_2	0.1667
p.S124F	SIDM00619	Thyroid Gland Carcinoma	GDSC	SKEND	DEG_APCC_KENBOX_2	0.1111
p.S124F	ACH-002397	Thyroid Cancer	CCLE	SKEND	DEG_APCC_KENBOX_2	0.1111
p.S124F	KMH-2	thyroid	COSMIC	SKEND	DEG_APCC_KENBOX_2	0.1111
p.L124P	OC-314	ovary	COSMIC	SKEND	DEG_APCC_KENBOX_2	0.1111
p.L109P	CCK-81	large_intestine	COSMIC	SKEND	DEG_APCC_KENBOX_2	0.25
p.I103V	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	SKEND	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43246	DNA mismatch repair protein Msh2	DEG_APCC_KENBOX_2	112:116	SKEND	APC,CDC20,FZR1	0.7326	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons