DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SLNTEEVPDF
Uniprot ID:
Q9UPX6
Source protein:
Major intrinsically disordered Notch2-binding receptor 1
Source gene:
MINAR1
Class:
DEG_COP1_1
Location:
370:379
E3 ligase:
COP1
DEGRON score:
0.9946
ASA_SCORE:
71.59
COIL:
0.7855
CONS_SCORE:
0.9618
DSS_SCORE:
0.4631
HELIX:
0.1845
FCONS_SCORE:
1.1942
RIG_SCORE:
0.7473
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R381W
SIDM00251
Gastric Carcinoma
GDSC
SLNTEEVPDF
DEG_COP1_1
0.2778
p.R381W
TGBC11TKB
stomach
COSMIC
SLNTEEVPDF
DEG_COP1_1
0.2778
Drug responses associated with MINAR1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SLNTEEVPDF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UPX6
Major intrinsically disordered Notch2-binding receptor 1
DEG_COP1_1
370:379
SLNTEEVPDF
COP1
0.9946
More...