DegronMD

Uniprot ID: Q969E2

Source protein: Secretory carrier-associated membrane protein 4

Source gene: SCAMP4

Class: DEG_COP1_1

Location: 212:222

E3 ligase: COP1

DEGRON score: 0.942

ASA_SCORE: 83.3455

COIL: 0.9408

CONS_SCORE: 0.262

DSS_SCORE: 0.5316

HELIX: 0.0185

FCONS_SCORE: 1.029

RIG_SCORE: 0.6611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S209L	TCGA-AC-A6IW	BRCA	TCGA	SLPEYPTVPSY	DEG_COP1_1	0.25
p.S209L	DO50028	BRCA	ICGC	SLPEYPTVPSY	DEG_COP1_1	0.25
p.E202Q	TCGA-CC-A9FS	LIHC	TCGA	SLPEYPTVPSY	DEG_COP1_1	0.0556
p.E202Q	DO219553	LIHC	ICGC	SLPEYPTVPSY	DEG_COP1_1	0.0556
p.F208L	TCGA-DK-A6AW	BLCA	TCGA	SLPEYPTVPSY	DEG_COP1_1	0.2222
p.F208L	DO48566	BLCA	ICGC	SLPEYPTVPSY	DEG_COP1_1	0.2222
p.P223L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	SLPEYPTVPSY	DEG_COP1_1	0.3056
p.P223L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SLPEYPTVPSY	DEG_COP1_1	0.3056
p.P223L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SLPEYPTVPSY	DEG_COP1_1	0.3056
p.P223L	ACH-000981	Leukemia	CCLE	SLPEYPTVPSY	DEG_COP1_1	0.3056
p.P223L	ACH-000995	Leukemia	CCLE	SLPEYPTVPSY	DEG_COP1_1	0.3056
p.P223L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	SLPEYPTVPSY	DEG_COP1_1	0.3056
p.P223L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	SLPEYPTVPSY	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q969E2	Secretory carrier-associated membrane protein 4	DEG_COP1_1	212:222	SLPEYPTVPSY	COP1	0.942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons