DegronMD

Uniprot ID: Q0D2I5

Source protein: Non-homologous end joining factor IFFO1

Source gene: IFFO1

Class: DEG_APCC_TPR_1

Location: 557:559

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6179

ASA_SCORE: 145.1333

COIL: 0.9107

CONS_SCORE: 0.5376

DSS_SCORE: 0.9785

HELIX: 0.0943

FCONS_SCORE: 1.0037

RIG_SCORE: 0.5999

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E548K	TCGA-PL-A8LV	BRCA	TCGA	SMR	DEG_APCC_TPR_1	0.0833
p.E547K	DO51215	BRCA	ICGC	SMR	DEG_APCC_TPR_1	0.0556
p.S559R	DO229045	LICA	ICGC	SMR	DEG_APCC_TPR_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0D2I5	Non-homologous end joining factor IFFO1	DEG_APCC_TPR_1	557:559	SMR	APC,CDC20,FZR1	0.6179	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons