DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
SNSLTVPTP
Uniprot ID:
Q9Y6F6
Source protein:
Inositol 1,4,5-triphosphate receptor associated 1
Source gene:
IRAG1
Class:
DEG_COP1_1
Location:
199:207
E3 ligase:
COP1
DEGRON score:
0.9939
ASA_SCORE:
88.1778
COIL:
0.9428
CONS_SCORE:
0.5578
DSS_SCORE:
0.6902
HELIX:
0.0334
FCONS_SCORE:
1.0415
RIG_SCORE:
0.5614
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with IRAG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SNSLTVPTP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y6F6
Inositol 1,4,5-triphosphate receptor associated 1
DEG_COP1_1
199:207
SNSLTVPTP
COP1
0.9939
More...