DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SPGEDGFVPSA
Uniprot ID:
Q5JPI9
Source protein:
EEF1A lysine methyltransferase 2
Source gene:
EEF1AKMT2
Class:
DEG_COP1_1
Location:
21:31
E3 ligase:
COP1
DEGRON score:
0.9974
ASA_SCORE:
70.8182
COIL:
0.9044
CONS_SCORE:
0.4293
DSS_SCORE:
0.582
HELIX:
0.0707
FCONS_SCORE:
1.0869
RIG_SCORE:
0.6426
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with EEF1AKMT2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SPGEDGFVPSA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5JPI9
EEF1A lysine methyltransferase 2
DEG_COP1_1
21:31
SPGEDGFVPSA
COP1
0.9974
More...