DegronMD

Uniprot ID: P78347

Source protein: General transcription factor II-I

Source gene: GTF2I

Class: DEG_COP1_1

Location: 674:684

E3 ligase: COP1

DEGRON score: 0.9825

ASA_SCORE: 83.5545

COIL: 0.8942

CONS_SCORE: 0.7994

DSS_SCORE: 0.6919

HELIX: 0.0405

FCONS_SCORE: 1.0741

RIG_SCORE: 0.5684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S668P	TCGA-AA-3715	COAD	TCGA	SPGSNSKVPEI	DEG_COP1_1	0.6111
p.E689Q	TCGA-ZF-AA51	BLCA	TCGA	SPGSNSKVPEI	DEG_COP1_1	0.1944
p.E668Q	DO219093	BLCA	ICGC	SPGSNSKVPEI	DEG_COP1_1	0.6111
p.V691I	DO228454	PRAD	ICGC	SPGSNSKVPEI	DEG_COP1_1	0.1389
p.T687A	ACH-000989	Colon/Colorectal Cancer	CCLE	SPGSNSKVPEI	DEG_COP1_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78347	General transcription factor II-I	DEG_COP1_1	674:684	SPGSNSKVPEI	COP1	0.9825	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons