DegronMD

Uniprot ID: Q00613

Source protein: Heat shock factor protein 1

Source gene: HSF1

Class: DEG_COP1_1

Location: 419:427

E3 ligase: COP1

DEGRON score: 0.8249

ASA_SCORE: 73.8667

COIL: 0.9169

CONS_SCORE: 0.3323

DSS_SCORE: 0.2884

HELIX: 0.0548

FCONS_SCORE: 0.9481

RIG_SCORE: 0.7448

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P425S	TCGA-27-1833	GBM	TCGA	SPSVTVPDM	DEG_COP1_1	0.6752
p.P425S	DO12976	GBM	ICGC	SPSVTVPDM	DEG_COP1_1	0.6752
p.P420L	TCGA-CM-6165	COAD	TCGA	SPSVTVPDM	DEG_COP1_1	0.6471
p.P420L	DO9900	COAD	ICGC	SPSVTVPDM	DEG_COP1_1	0.6471
p.P430H	TCGA-D3-A2JC	SKCM	TCGA	SPSVTVPDM	DEG_COP1_1	0.25
p.P430H	DO47578	SKCM	ICGC	SPSVTVPDM	DEG_COP1_1	0.25
p.S421L	DO48409	BLCA	ICGC	SPSVTVPDM	DEG_COP1_1	0.7667
p.R419C	DO223703	COAD	ICGC	SPSVTVPDM	DEG_COP1_1	0.8301
p.R419C	ACH-000961	Endometrial/Uterine Cancer	CCLE	SPSVTVPDM	DEG_COP1_1	0.8301
p.A427V	DO234219	ESAD	ICGC	SPSVTVPDM	DEG_COP1_1	0.6936
p.A437S	DO228900	LICA	ICGC	SPSVTVPDM	DEG_COP1_1	0.0556
p.S428I	DO228986	LICA	ICGC	SPSVTVPDM	DEG_COP1_1	0.3056
p.S435N	DO231821	LINC	ICGC	SPSVTVPDM	DEG_COP1_1	0.1111
p.R417W	DO45299	LIRI	ICGC	SPSVTVPDM	DEG_COP1_1	0.2778
p.S419G	DO229257	THCA	ICGC	SPSVTVPDM	DEG_COP1_1	0.8104
p.S421W	SIDM01004	Chronic Myelogenous Leukemia	GDSC	SPSVTVPDM	DEG_COP1_1	0.7874
p.S421W	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	SPSVTVPDM	DEG_COP1_1	0.7874
p.S419R	SIDM01004	Chronic Myelogenous Leukemia	GDSC	SPSVTVPDM	DEG_COP1_1	0.8538
p.S419R	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	SPSVTVPDM	DEG_COP1_1	0.8538
p.V424M	SIDM00845	Burkitt's Lymphoma	GDSC	SPSVTVPDM	DEG_COP1_1	0.7208
p.V424M	SIDM01652	Non-Cancerous	GDSC	SPSVTVPDM	DEG_COP1_1	0.7208
p.V424M	SIDM00187	Kidney Carcinoma	GDSC	SPSVTVPDM	DEG_COP1_1	0.7208
p.T411S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SPSVTVPDM	DEG_COP1_1	0.1111
p.T411S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SPSVTVPDM	DEG_COP1_1	0.1111
p.V422L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPSVTVPDM	DEG_COP1_1	0.5654
p.V422L	ACH-001127	Leukemia	CCLE	SPSVTVPDM	DEG_COP1_1	0.5654
p.V422L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SPSVTVPDM	DEG_COP1_1	0.5654
p.G428S	ACH-001061	Colon/Colorectal Cancer	CCLE	SPSVTVPDM	DEG_COP1_1	0.3056
p.M429V	HN	upper_aerodigestive_tract	COSMIC	SPSVTVPDM	DEG_COP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SPSVTVPDM

Degron related mutations and impact score

Drug responses associated with HSF1 mutations

All proteins holding degron of SPSVTVPDM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00613	Heat shock factor protein 1	DEG_COP1_1	419:427	SPSVTVPDM	COP1	0.8249	More...