DegronMD

Uniprot ID: P17096

Source protein: High mobility group protein HMG-I/HMG-Y

Source gene: HMGA1

Class: DEG_COP1_1

Location: 44:54

E3 ligase: COP1

DEGRON score: 0.9909

ASA_SCORE: 102.8727

COIL: 0.9485

CONS_SCORE: 1

DSS_SCORE: 0.8419

HELIX: 0.019

FCONS_SCORE: 1.0121

RIG_SCORE: 0.5804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A40T	TCGA-AD-5900	COAD	TCGA	SQKEPSEVPTP	DEG_COP1_1	0.2222
p.A40T	DO8514	COAD	ICGC	SQKEPSEVPTP	DEG_COP1_1	0.2222
p.R58W	TCGA-CG-4306	STAD	TCGA	SQKEPSEVPTP	DEG_COP1_1	0.2222
p.R58W	DO38567	STAD	ICGC	SQKEPSEVPTP	DEG_COP1_1	0.2222
p.K55N	TCGA-Q1-A73P	CESC	TCGA	SQKEPSEVPTP	DEG_COP1_1	0.75
p.K55N	DO49983	CESC	ICGC	SQKEPSEVPTP	DEG_COP1_1	0.75
p.G59V	DO233693	GACA	ICGC	SQKEPSEVPTP	DEG_COP1_1	0.1944
p.Q45H	DO228948	LICA	ICGC	SQKEPSEVPTP	DEG_COP1_1	0.647
p.E50K	DO228142	PBCA	ICGC	SQKEPSEVPTP	DEG_COP1_1	0.591
p.P48S	DO229250	THCA	ICGC	SQKEPSEVPTP	DEG_COP1_1	0.5641
p.A40V	DO41199	UCEC	ICGC	SQKEPSEVPTP	DEG_COP1_1	0.2222
p.A59D	LNCaP-Clone-FGC	prostate	COSMIC	SQKEPSEVPTP	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17096	High mobility group protein HMG-I/HMG-Y	DEG_COP1_1	44:54	SQKEPSEVPTP	COP1	0.9909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons