DegronMD

Uniprot ID: Q9Y6E0

Source protein: Serine/threonine-protein kinase 24

Source gene: STK24

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9962

ASA_SCORE: 96.3111

COIL: 0.5196

CONS_SCORE: 0.2381

DSS_SCORE: 0.5817

HELIX: 0.4629

FCONS_SCORE: 1.2243

RIG_SCORE: 0.7955

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q6H	TCGA-A5-A0G2	UCEC	TCGA	SRAQLWGLA	DEG_APCC_DBOX_1	0.647
p.Q6H	DO228483	BRCA	ICGC	SRAQLWGLA	DEG_APCC_DBOX_1	0.647
p.Q6H	DO41235	UCEC	ICGC	SRAQLWGLA	DEG_APCC_DBOX_1	0.647
p.G9R	SIDM00333	Endometrial Carcinoma	GDSC	SRAQLWGLA	DEG_APCC_DBOX_1	0.6457
p.G9R	ACH-000988	Endometrial/Uterine Cancer	CCLE	SRAQLWGLA	DEG_APCC_DBOX_1	0.6457
p.G9R	MFE-319	endometrium	COSMIC	SRAQLWGLA	DEG_APCC_DBOX_1	0.6457
p.A18E	DO229019	LICA	ICGC	SRAQLWGLA	DEG_APCC_DBOX_1	0.5833
p.A2V	DO227802	COCA	ICGC	SRAQLWGLA	DEG_APCC_DBOX_1	0.4167
p.K17N	DO51197	LUAD	ICGC	SRAQLWGLA	DEG_APCC_DBOX_1	0.1667
p.A17T	ACH-001611	Brain Cancer	CCLE	SRAQLWGLA	DEG_APCC_DBOX_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6E0	Serine/threonine-protein kinase 24	DEG_APCC_DBOX_1	3:11	SRAQLWGLA	APC,CDC20,FZR1	0.9962	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons