DegronMD

Uniprot ID: Q9C0C7

Source protein: Activating molecule in BECN1-regulated autophagy protein 1

Source gene: AMBRA1

Class: DEG_COP1_1

Location: 312:322

E3 ligase: COP1

DEGRON score: 0.6415

ASA_SCORE: 70.5636

COIL: 0.7795

CONS_SCORE: 0.3987

DSS_SCORE: 0.0954

HELIX: 0.0392

FCONS_SCORE: 1.0028

RIG_SCORE: 0.7459

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E328K	TCGA-30-1855	OV	TCGA	SRCSGTRVPSL	DEG_COP1_1	0.6111
p.E328K	DO32666	OV	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.6111
p.S310C	TCGA-D1-A16J	UCEC	TCGA	SRCSGTRVPSL	DEG_COP1_1	0.2778
p.S310C	DO43033	UCEC	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.2778
p.P313S	TCGA-D3-A1QB	SKCM	TCGA	SRCSGTRVPSL	DEG_COP1_1	0.6752
p.P313S	DO47573	SKCM	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.6752
p.R331Q	TCGA-GN-A263	SKCM	TCGA	SRCSGTRVPSL	DEG_COP1_1	0.0833
p.R331Q	DO37766	SKCM	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.0833
p.R331Q	ACH-002222	Leukemia	CCLE	SRCSGTRVPSL	DEG_COP1_1	0.0833
p.R331Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRCSGTRVPSL	DEG_COP1_1	0.0833
p.E328Q	TCGA-Q1-A73P	CESC	TCGA	SRCSGTRVPSL	DEG_COP1_1	0.6111
p.E328Q	DO49983	CESC	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.6111
p.R303H	TCGA-XK-AAIW	PRAD	TCGA	SRCSGTRVPSL	DEG_COP1_1	0.0833
p.R303H	DO51407	PRAD	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.0833
p.R313H	DO13863	GBM	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.7133
p.R313H	DO36556	READ	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.7133
p.L322I	DO26758	LUSC	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.6063
p.L305F	DO37487	SKCM	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.1389
p.L310F	DO38123	SKCM	ICGC	SRCSGTRVPSL	DEG_COP1_1	0.2778
p.S328N	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRCSGTRVPSL	DEG_COP1_1	0.6111
p.S328N	ACH-002272	Lymphoma	CCLE	SRCSGTRVPSL	DEG_COP1_1	0.6111
p.S328N	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRCSGTRVPSL	DEG_COP1_1	0.6111
p.S315A	SIDM00845	Burkitt's Lymphoma	GDSC	SRCSGTRVPSL	DEG_COP1_1	0.7588
p.S315A	SIDM00461	Acute Myeloid Leukemia	GDSC	SRCSGTRVPSL	DEG_COP1_1	0.7588
p.S315A	SIDM01519	Head and Neck Carcinoma	GDSC	SRCSGTRVPSL	DEG_COP1_1	0.7588
p.S315A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SRCSGTRVPSL	DEG_COP1_1	0.7588
p.R318Q	SIDM00301	Pancreatic Carcinoma	GDSC	SRCSGTRVPSL	DEG_COP1_1	0.6218
p.R318Q	SIDM01336	Glioblastoma	GDSC	SRCSGTRVPSL	DEG_COP1_1	0.6218
p.R318Q	SIDM01442	Glioma	GDSC	SRCSGTRVPSL	DEG_COP1_1	0.6218
p.R318Q	KP-4	pancreas	COSMIC	SRCSGTRVPSL	DEG_COP1_1	0.6218
p.H317Y	ACH-000921	Lung Cancer	CCLE	SRCSGTRVPSL	DEG_COP1_1	0.7229
p.G307A	ACH-002024	Colon/Colorectal Cancer	CCLE	SRCSGTRVPSL	DEG_COP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRCSGTRVPSL

Degron related mutations and impact score

Drug responses associated with AMBRA1 mutations

All proteins holding degron of SRCSGTRVPSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_COP1_1	312:322	SRCSGTRVPSL	COP1	0.6415	More...