DegronMD

Uniprot ID: Q16760

Source protein: Diacylglycerol kinase delta

Source gene: DGKD

Class: DEG_APCC_DBOX_1

Location: 708:716

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8732

ASA_SCORE: 66.1333

COIL: 0.7976

CONS_SCORE: 0.3296

DSS_SCORE: 0.4865

HELIX: 0.1331

FCONS_SCORE: 0.9699

RIG_SCORE: 0.6784

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S698R	TCGA-78-7147	LUAD	TCGA	SRDGLPALN	DEG_APCC_DBOX_1	0.0556
p.S698R	DO24527	LUAD	ICGC	SRDGLPALN	DEG_APCC_DBOX_1	0.0556
p.R725Q	TCGA-DF-A2KU	UCEC	TCGA	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.R725Q	DO223286	UCEC	ICGC	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.R725Q	SIDM00488	Colorectal Carcinoma	GDSC	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.R725Q	SIDM00561	Other Blood Cancers	GDSC	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.R725Q	SIDM01735	Biliary Tract Carcinoma	GDSC	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.R725Q	ACH-000808	Bile Duct Cancer	CCLE	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.R725Q	ACH-002274	Leukemia	CCLE	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.R725Q	ACH-002345	Colon/Colorectal Cancer	CCLE	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.R725Q	CaR-1	large_intestine	COSMIC	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.R725Q	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	SRDGLPALN	DEG_APCC_DBOX_1	0.0833
p.S701F	TCGA-EB-A5UM	SKCM	TCGA	SRDGLPALN	DEG_APCC_DBOX_1	0.1389
p.S701F	DO47282	SKCM	ICGC	SRDGLPALN	DEG_APCC_DBOX_1	0.1389
p.G711D	TCGA-FI-A2F4	UCEC	TCGA	SRDGLPALN	DEG_APCC_DBOX_1	0.6087
p.G711D	DO43434	UCEC	ICGC	SRDGLPALN	DEG_APCC_DBOX_1	0.6087
p.P703L	TCGA-MP-A4SV	LUAD	TCGA	SRDGLPALN	DEG_APCC_DBOX_1	0.1944
p.P703L	DO45339	LUAD	ICGC	SRDGLPALN	DEG_APCC_DBOX_1	0.1944
p.S698I	DO229008	LICA	ICGC	SRDGLPALN	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16760	Diacylglycerol kinase delta	DEG_APCC_DBOX_1	708:716	SRDGLPALN	APC,CDC20,FZR1	0.8732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons