DegronMD

Uniprot ID: Q00653

Source protein: Nuclear factor NF-kappa-B p100 subunit

Source gene: NFKB2

Class: DEG_Kelch_Keap1_1

Location: 413:418

E3 ligase: KEAP1

DEGRON score: 0.9952

ASA_SCORE: 77.8667

COIL: 0.7912

CONS_SCORE: 0.3887

DSS_SCORE: 0.7221

HELIX: 0.1478

FCONS_SCORE: 1.138

RIG_SCORE: 0.5807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A409V	DO230309	COCA	ICGC	SRDSGE	DEG_Kelch_Keap1_1	0.2222
p.M407I	DO229035	LICA	ICGC	SRDSGE	DEG_Kelch_Keap1_1	0.1667
p.A409D	DO229250	THCA	ICGC	SRDSGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00653	Nuclear factor NF-kappa-B p100 subunit	DEG_Kelch_Keap1_1	413:418	SRDSGE	KEAP1	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons