DegronMD

Uniprot ID: Q96FS4

Source protein: Signal-induced proliferation-associated protein 1

Source gene: SIPA1

Class: DEG_APCC_DBOX_1

Location: 553:561

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9298

ASA_SCORE: 65.4667

COIL: 0.7737

CONS_SCORE: 0.2848

DSS_SCORE: 0.5063

HELIX: 0.1221

FCONS_SCORE: 0.9928

RIG_SCORE: 0.6906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R569W	DO223002	ESCA	ICGC	SRFGLPSLG	DEG_APCC_DBOX_1	0.1111
p.R569W	ACH-000821	Myeloma	CCLE	SRFGLPSLG	DEG_APCC_DBOX_1	0.1111
p.L560V	DO26769	LUSC	ICGC	SRFGLPSLG	DEG_APCC_DBOX_1	0.5654
p.SP562SS	DO222908	MELA	ICGC	SRFGLPSLG	DEG_APCC_DBOX_1	0
p.A567T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SRFGLPSLG	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FS4	Signal-induced proliferation-associated protein 1	DEG_APCC_DBOX_1	553:561	SRFGLPSLG	APC,CDC20,FZR1	0.9298	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons