DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
SRFLLVLLS
Uniprot ID:
Q86SQ3
Source protein:
Putative adhesion G protein-coupled receptor E4P
Source gene:
ADGRE4P
Class:
DEG_APCC_DBOX_1
Location:
3:11
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8111
ASA_SCORE:
71.9556
COIL:
0.4694
CONS_SCORE:
0.2875
DSS_SCORE:
0.2538
HELIX:
0.0322
FCONS_SCORE:
2.4111
RIG_SCORE:
0.8582
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ADGRE4P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRFLLVLLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86SQ3
Putative adhesion G protein-coupled receptor E4P
DEG_APCC_DBOX_1
3:11
SRFLLVLLS
APC,CDC20,FZR1
0.8111
More...