DegronMD

Uniprot ID: Q5FWF6

Source protein: Zinc finger protein 789

Source gene: ZNF789

Class: DEG_APCC_DBOX_1

Location: 151:159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.94

ASA_SCORE: 72.6111

COIL: 0.6893

CONS_SCORE: 0.8073

DSS_SCORE: 0.3537

HELIX: 0.119

FCONS_SCORE: 1.1564

RIG_SCORE: 0.8282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P144S	TCGA-2H-A9GJ	ESCA	TCGA	SRGFLQNLN	DEG_APCC_DBOX_1	0.1389
p.S151N	TCGA-A5-A1OF	UCEC	TCGA	SRGFLQNLN	DEG_APCC_DBOX_1	0.5958
p.S151N	DO42568	UCEC	ICGC	SRGFLQNLN	DEG_APCC_DBOX_1	0.5958
p.A166V	TCGA-AP-A0LM	UCEC	TCGA	SRGFLQNLN	DEG_APCC_DBOX_1	0.1389
p.A166V	TCGA-AX-A0J1	UCEC	TCGA	SRGFLQNLN	DEG_APCC_DBOX_1	0.1389
p.A166V	DO43306	UCEC	ICGC	SRGFLQNLN	DEG_APCC_DBOX_1	0.1389
p.A166V	DO41199	UCEC	ICGC	SRGFLQNLN	DEG_APCC_DBOX_1	0.1389
p.A166V	SIDM01608	Endometrial Carcinoma	GDSC	SRGFLQNLN	DEG_APCC_DBOX_1	0.1389
p.A166V	ACH-000990	Endometrial/Uterine Cancer	CCLE	SRGFLQNLN	DEG_APCC_DBOX_1	0.1389
p.R152K	TCGA-EE-A20C	SKCM	TCGA	SRGFLQNLN	DEG_APCC_DBOX_1	0.7237
p.R152K	DO222775	MELA	ICGC	SRGFLQNLN	DEG_APCC_DBOX_1	0.7237
p.R152K	DO47665	SKCM	ICGC	SRGFLQNLN	DEG_APCC_DBOX_1	0.7237
p.Q156E	TCGA-P3-A6T3	HNSC	TCGA	SRGFLQNLN	DEG_APCC_DBOX_1	0.5633
p.Q156E	DO49055	HNSC	ICGC	SRGFLQNLN	DEG_APCC_DBOX_1	0.5633
p.Q156E	DO231467	THCA	ICGC	SRGFLQNLN	DEG_APCC_DBOX_1	0.5633
p.G153S	DO51964	PRAD	ICGC	SRGFLQNLN	DEG_APCC_DBOX_1	0.5882
p.D148G	SIDM01009	Neuroblastoma	GDSC	SRGFLQNLN	DEG_APCC_DBOX_1	0.25
p.D148G	KELLY	autonomic_ganglia	COSMIC	SRGFLQNLN	DEG_APCC_DBOX_1	0.25
p.Y150H	SIDM00534	Colorectal Carcinoma	GDSC	SRGFLQNLN	DEG_APCC_DBOX_1	0.3056
p.Y150H	ACH-000986	Colon/Colorectal Cancer	CCLE	SRGFLQNLN	DEG_APCC_DBOX_1	0.3056
p.Y150H	HT-115	large_intestine	COSMIC	SRGFLQNLN	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5FWF6	Zinc finger protein 789	DEG_APCC_DBOX_1	151:159	SRGFLQNLN	APC,CDC20,FZR1	0.94	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons