DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
SRGPLHILG
Uniprot ID:
Q9H0H9
Source protein:
Putative cytochrome P450 family member 4F30
Source gene:
CYP4F30P
Class:
DEG_APCC_DBOX_1
Location:
53:61
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7774
ASA_SCORE:
46.4222
COIL:
0.5446
CONS_SCORE:
1
DSS_SCORE:
0.5974
HELIX:
0.0633
FCONS_SCORE:
1.0476
RIG_SCORE:
0.6593
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CYP4F30P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRGPLHILG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H0H9
Putative cytochrome P450 family member 4F30
DEG_APCC_DBOX_1
53:61
SRGPLHILG
APC,CDC20,FZR1
0.7774
More...