DegronMD

Uniprot ID: Q6UXM1

Source protein: Leucine-rich repeats and immunoglobulin-like domains protein 3

Source gene: LRIG3

Class: DEG_APCC_DBOX_1

Location: 61:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.596

ASA_SCORE: 78.2556

COIL: 0.7392

CONS_SCORE: 0.4461

DSS_SCORE: 0.1252

HELIX: 0.0212

FCONS_SCORE: 0.9923

RIG_SCORE: 0.8068

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P71Q	DO228199	LICA	ICGC	SRKRLARLP	DEG_APCC_DBOX_1	0.2778
p.R78G	DO27326	LUSC	ICGC	SRKRLARLP	DEG_APCC_DBOX_1	0.0833
p.D56H	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRKRLARLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXM1	Leucine-rich repeats and immunoglobulin-like domains protein 3	DEG_APCC_DBOX_1	61:69	SRKRLARLP	APC,CDC20,FZR1	0.596	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons