DegronMD

Uniprot ID: Q6P1L6

Source protein: Zinc finger protein 343

Source gene: ZNF343

Class: DEG_APCC_DBOX_1

Location: 559:567

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9132

ASA_SCORE: 78.3222

COIL: 0.6777

CONS_SCORE: 0.5368

DSS_SCORE: 0.2707

HELIX: 0.1442

FCONS_SCORE: 0.7153

RIG_SCORE: 0.794

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R560G	DO220906	MELA	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.7568
p.L564H	TCGA-FS-A1ZP	SKCM	TCGA	SRKSLLLVH	DEG_APCC_DBOX_1	0.6202
p.L564H	DO37703	SKCM	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.6202
p.L564I	TCGA-D3-A2JC	SKCM	TCGA	SRKSLLLVH	DEG_APCC_DBOX_1	0.6063
p.L564I	DO47578	SKCM	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.6063
p.L565I	ACH-000990	Endometrial/Uterine Cancer	CCLE	SRKSLLLVH	DEG_APCC_DBOX_1	0.6063
p.L565F	ACH-000216	Esophageal Cancer	CCLE	SRKSLLLVH	DEG_APCC_DBOX_1	0.587
p.G555S	TCGA-GM-A2D9	BRCA	TCGA	SRKSLLLVH	DEG_APCC_DBOX_1	0.2222
p.G555S	DO4810	BRCA	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.2222
p.C554F	TCGA-NK-A5CT	LUSC	TCGA	SRKSLLLVH	DEG_APCC_DBOX_1	0.1944
p.C554F	DO219209	LUSC	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.1944
p.E553K	TCGA-E5-A4U1	BLCA	TCGA	SRKSLLLVH	DEG_APCC_DBOX_1	0.1667
p.E553K	DO44061	BLCA	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.1667
p.E574Q	TCGA-56-A4ZK	LUSC	TCGA	SRKSLLLVH	DEG_APCC_DBOX_1	0.1389
p.E574Q	DO45496	LUSC	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.1389
p.S552N	TCGA-BG-A222	UCEC	TCGA	SRKSLLLVH	DEG_APCC_DBOX_1	0.1389
p.S552N	DO42977	UCEC	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.1389
p.S552G	ACH-000643	Breast Cancer	CCLE	SRKSLLLVH	DEG_APCC_DBOX_1	0.1389
p.S552G	HDQ-P1	breast	COSMIC	SRKSLLLVH	DEG_APCC_DBOX_1	0.1389
p.H576P	DO234422	ESAD	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.0833
p.V550M	DO228638	GACA	ICGC	SRKSLLLVH	DEG_APCC_DBOX_1	0.0833
p.T576P	SIDM01347	Ovarian Carcinoma	GDSC	SRKSLLLVH	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P1L6	Zinc finger protein 343	DEG_APCC_DBOX_1	559:567	SRKSLLLVH	APC,CDC20,FZR1	0.9132	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons