DegronMD

Uniprot ID: Q5JNZ3

Source protein: Zinc finger protein 311

Source gene: ZNF311

Class: DEG_APCC_DBOX_1

Location: 645:653

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9717

ASA_SCORE: 70.5111

COIL: 0.6738

CONS_SCORE: 0.5548

DSS_SCORE: 0.4115

HELIX: 0.1137

FCONS_SCORE: 1.3324

RIG_SCORE: 0.6913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S655F	TCGA-D3-A51T	SKCM	TCGA	SRKSLSPVT	DEG_APCC_DBOX_1	0.2778
p.S655F	DO47389	SKCM	ICGC	SRKSLSPVT	DEG_APCC_DBOX_1	0.2778
p.T639I	DO234457	ESAD	ICGC	SRKSLSPVT	DEG_APCC_DBOX_1	0.1667
p.R646S	DO50928	LICA	ICGC	SRKSLSPVT	DEG_APCC_DBOX_1	0.7427
p.S655C	DO229539	UTCA	ICGC	SRKSLSPVT	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JNZ3	Zinc finger protein 311	DEG_APCC_DBOX_1	645:653	SRKSLSPVT	APC,CDC20,FZR1	0.9717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons