DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
SRNSLSGLR
Uniprot ID:
Q8NCU4
Source protein:
Coiled-coil domain-containing protein 191
Source gene:
CCDC191
Class:
DEG_APCC_DBOX_1
Location:
637:645
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9434
ASA_SCORE:
98.6
COIL:
0.7537
CONS_SCORE:
0.3462
DSS_SCORE:
0.709
HELIX:
0.2382
FCONS_SCORE:
1.0106
RIG_SCORE:
0.6185
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CCDC191 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRNSLSGLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NCU4
Coiled-coil domain-containing protein 191
DEG_APCC_DBOX_1
637:645
SRNSLSGLR
APC,CDC20,FZR1
0.9434
More...