DegronMD

Uniprot ID: Q9NZJ0

Source protein: Denticleless protein homolog

Source gene: DTL

Class: DEG_APCC_DBOX_1

Location: 416:424

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8187

ASA_SCORE: 67.2111

COIL: 0.5673

CONS_SCORE: 0.3778

DSS_SCORE: 0.6241

HELIX: 0.0843

FCONS_SCORE: 0.8874

RIG_SCORE: 0.6735

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P423L	DO51298	SKCM	ICGC	SRPGLVTVT	DEG_APCC_DBOX_1	0.7582
p.T424M	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SRPGLVTVT	DEG_APCC_DBOX_1	0.7423
p.T424M	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SRPGLVTVT	DEG_APCC_DBOX_1	0.7423
p.T424M	SIDM00032	Bladder Carcinoma	GDSC	SRPGLVTVT	DEG_APCC_DBOX_1	0.7423
p.T424M	SIDM00907	Burkitt's Lymphoma	GDSC	SRPGLVTVT	DEG_APCC_DBOX_1	0.7423
p.R417K	TCGA-AP-A0LM	UCEC	TCGA	SRPGLVTVT	DEG_APCC_DBOX_1	0.7237
p.L418F	NCI-H526	lung	COSMIC	SRPGLVTVT	DEG_APCC_DBOX_1	0.6981
p.L418V	DO45347	LUAD	ICGC	SRPGLVTVT	DEG_APCC_DBOX_1	0.6765
p.A432S	H9	haematopoietic_and_lymphoid_tissue	COSMIC	SRPGLVTVT	DEG_APCC_DBOX_1	0.5556
p.A409S	DO229026	LICA	ICGC	SRPGLVTVT	DEG_APCC_DBOX_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZJ0	Denticleless protein homolog	DEG_APCC_DBOX_1	416:424	SRPGLVTVT	APC,CDC20,FZR1	0.8187	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons