DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRPPLSRLV
Uniprot ID:
Q9BW85
Source protein:
Splicing factor YJU2
Source gene:
YJU2
Class:
DEG_APCC_DBOX_1
Location:
256:264
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9159
ASA_SCORE:
81.8222
COIL:
0.7323
CONS_SCORE:
0.3442
DSS_SCORE:
0.4761
HELIX:
0.1969
FCONS_SCORE:
1.1929
RIG_SCORE:
0.713
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A271G
SIDM00337
Melanoma
GDSC
SRPPLSRLV
DEG_APCC_DBOX_1
0.1389
p.A271G
MEL-HO
skin
COSMIC
SRPPLSRLV
DEG_APCC_DBOX_1
0.1389
Drug responses associated with YJU2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRPPLSRLV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BW85
Splicing factor YJU2
DEG_APCC_DBOX_1
256:264
SRPPLSRLV
APC,CDC20,FZR1
0.9159
More...