DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_APCC_DBOX_1

Location: 1185:1193

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6289

ASA_SCORE: 75.0222

COIL: 0.412

CONS_SCORE: 0.4006

DSS_SCORE: 0.468

HELIX: 0.0289

FCONS_SCORE: 1.0784

RIG_SCORE: 0.7449

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1188W	TCGA-FI-A2D0	UCEC	TCGA	SRPRLTILN	DEG_APCC_DBOX_1	0.7523
p.G1198V	TCGA-GN-A26C	SKCM	TCGA	SRPRLTILN	DEG_APCC_DBOX_1	0.1944
p.S1179Y	TCGA-XF-A8HD	BLCA	TCGA	SRPRLTILN	DEG_APCC_DBOX_1	0.1667
p.P1188L	DO220913	MELA	ICGC	SRPRLTILN	DEG_APCC_DBOX_1	0.7582
p.G1192D	DO222632	MELA	ICGC	SRPRLTILN	DEG_APCC_DBOX_1	0.7198
p.E1203K	DO220011	SARC	ICGC	SRPRLTILN	DEG_APCC_DBOX_1	0.0556
p.P1189T	DO37404	SKCM	ICGC	SRPRLTILN	DEG_APCC_DBOX_1	0.7031
p.D1183N	DO47329	SKCM	ICGC	SRPRLTILN	DEG_APCC_DBOX_1	0.2778
p.R1176H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	SRPRLTILN	DEG_APCC_DBOX_1	0.0833
p.R1176H	ACH-000922	Leukemia	CCLE	SRPRLTILN	DEG_APCC_DBOX_1	0.0833
p.R1176H	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	SRPRLTILN	DEG_APCC_DBOX_1	0.0833
p.R1178L	SIDM01387	Small Cell Lung Carcinoma	GDSC	SRPRLTILN	DEG_APCC_DBOX_1	0.1389
p.R1178L	ACH-000921	Lung Cancer	CCLE	SRPRLTILN	DEG_APCC_DBOX_1	0.1389
p.E1182K	ACH-001982	Metastasis	CCLE	SRPRLTILN	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_APCC_DBOX_1	1185:1193	SRPRLTILN	APC,CDC20,FZR1	0.6289	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons