DegronMD

Uniprot ID: P41091

Source protein: Eukaryotic translation initiation factor 2 subunit 3

Source gene: EIF2S3

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7956

ASA_SCORE: 75.6667

COIL: 0.6799

CONS_SCORE: 0.3365

DSS_SCORE: 0.3839

HELIX: 0.2446

FCONS_SCORE: 0.9463

RIG_SCORE: 0.7951

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E34K	TCGA-AP-A1DV	UCEC	TCGA	SRQDLTTLD	DEG_APCC_DBOX_1	0.0556
p.E34K	TCGA-EO-A3B0	UCEC	TCGA	SRQDLTTLD	DEG_APCC_DBOX_1	0.0556
p.E34K	DO219773	UCEC	ICGC	SRQDLTTLD	DEG_APCC_DBOX_1	0.0556
p.E34K	DO43186	UCEC	ICGC	SRQDLTTLD	DEG_APCC_DBOX_1	0.0556
p.L20I	TCGA-CN-6010	HNSC	TCGA	SRQDLTTLD	DEG_APCC_DBOX_1	0.7174
p.L20I	DO14766	HNSC	ICGC	SRQDLTTLD	DEG_APCC_DBOX_1	0.7174
p.D24G	TCGA-D1-A17Q	UCEC	TCGA	SRQDLTTLD	DEG_APCC_DBOX_1	0.6087
p.D24G	DO41903	UCEC	ICGC	SRQDLTTLD	DEG_APCC_DBOX_1	0.6087
p.Q18E	DO233708	GACA	ICGC	SRQDLTTLD	DEG_APCC_DBOX_1	0.5633
p.G7V	DO229213	THCA	ICGC	SRQDLTTLD	DEG_APCC_DBOX_1	0.5278
p.L20F	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	SRQDLTTLD	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41091	Eukaryotic translation initiation factor 2 subunit 3	DEG_APCC_DBOX_1	16:24	SRQDLTTLD	APC,CDC20,FZR1	0.7956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons