DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRSTLTTLP
Uniprot ID:
Q96GV9
Source protein:
Macrophage immunometabolism regulator
Source gene:
MACIR
Class:
DEG_APCC_DBOX_1
Location:
9:17
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6764
ASA_SCORE:
60.9333
COIL:
0.5368
CONS_SCORE:
0.6013
DSS_SCORE:
0.6156
HELIX:
0.0392
FCONS_SCORE:
0.9541
RIG_SCORE:
0.7052
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E22A
SIDM00981
B-Cell Non-Hodgkin's Lymphoma
GDSC
SRSTLTTLP
DEG_APCC_DBOX_1
0.1944
p.E22A
SIDM00332
Breast Carcinoma
GDSC
SRSTLTTLP
DEG_APCC_DBOX_1
0.1944
Drug responses associated with MACIR mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRSTLTTLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96GV9
Macrophage immunometabolism regulator
DEG_APCC_DBOX_1
9:17
SRSTLTTLP
APC,CDC20,FZR1
0.6764
More...