DegronMD

Uniprot ID: Q9NR48

Source protein: Histone-lysine N-methyltransferase ASH1L

Source gene: ASH1L

Class: DEG_APCC_DBOX_1

Location: 1507:1515

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.829

ASA_SCORE: 72.6778

COIL: 0.3183

CONS_SCORE: 0.3751

DSS_SCORE: 0.4971

HELIX: 0.6644

FCONS_SCORE: 1.0714

RIG_SCORE: 0.717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1516H	TCGA-85-8664	LUSC	TCGA	SRSVLESLK	DEG_APCC_DBOX_1	0.3056
p.R1516H	DO45469	LUSC	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.3056
p.M1502V	TCGA-A6-2686	COAD	TCGA	SRSVLESLK	DEG_APCC_DBOX_1	0.1944
p.M1502V	DO7828	COAD	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.1944
p.A1523V	TCGA-B5-A11E	UCEC	TCGA	SRSVLESLK	DEG_APCC_DBOX_1	0.1111
p.A1523V	DO41644	UCEC	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.1111
p.R1518S	TCGA-BR-A4QL	STAD	TCGA	SRSVLESLK	DEG_APCC_DBOX_1	0.25
p.R1518S	DO38723	STAD	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.25
p.R1516P	TCGA-DD-A73E	LIHC	TCGA	SRSVLESLK	DEG_APCC_DBOX_1	0.3056
p.R1516P	DO48483	LIHC	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.3056
p.G1505S	TCGA-FR-A726	SKCM	TCGA	SRSVLESLK	DEG_APCC_DBOX_1	0.2778
p.G1505S	DO48665	SKCM	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.2778
p.R1516C	TCGA-HU-8602	STAD	TCGA	SRSVLESLK	DEG_APCC_DBOX_1	0.3056
p.R1516C	DO47829	STAD	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.3056
p.T1504N	DO228974	LICA	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.25
p.R1516S	DO229035	LICA	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.3056
p.Q1497K	DO229041	LICA	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.0556
p.Y1517C	DO23362	LINC	ICGC	SRSVLESLK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_APCC_DBOX_1	1507:1515	SRSVLESLK	APC,CDC20,FZR1	0.829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons