DegronMD

Uniprot ID: Q9NR48

Source protein: Histone-lysine N-methyltransferase ASH1L

Source gene: ASH1L

Class: DEG_APCC_DBOX_1

Location: 1456:1464

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9792

ASA_SCORE: 73.8222

COIL: 0.7928

CONS_SCORE: 0.3643

DSS_SCORE: 0.3819

HELIX: 0.1603

FCONS_SCORE: 0.9166

RIG_SCORE: 0.7441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1465A	TCGA-AA-3833	COAD	TCGA	SRTPLLSMS	DEG_APCC_DBOX_1	0.3056
p.T1465A	DO9796	COAD	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.3056
p.E1450D	TCGA-AX-A2HC	UCEC	TCGA	SRTPLLSMS	DEG_APCC_DBOX_1	0.1667
p.E1450D	DO41572	UCEC	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.1667
p.E1450K	TCGA-D3-A8GL	SKCM	TCGA	SRTPLLSMS	DEG_APCC_DBOX_1	0.1667
p.E1450K	DO50287	SKCM	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.1667
p.S1468I	TCGA-EJ-5495	PRAD	TCGA	SRTPLLSMS	DEG_APCC_DBOX_1	0.2222
p.S1468I	DO36258	PRAD	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.2222
p.P1471L	TCGA-FS-A1ZM	SKCM	TCGA	SRTPLLSMS	DEG_APCC_DBOX_1	0.1389
p.P1471L	DO37731	SKCM	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.1389
p.L1453V	TCGA-G2-A3VY	BLCA	TCGA	SRTPLLSMS	DEG_APCC_DBOX_1	0.25
p.L1453V	DO590	BLCA	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.25
p.S1468C	TCGA-UY-A78N	BLCA	TCGA	SRTPLLSMS	DEG_APCC_DBOX_1	0.2222
p.S1468C	DO219034	BLCA	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.2222
p.P1459A	DO225089	BRCA	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.6392
p.P1471S	DO222731	MELA	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.1389
p.P1471S	SIDM00516	Melanoma	GDSC	SRTPLLSMS	DEG_APCC_DBOX_1	0.1389
p.P1471S	ACH-002166	Skin Cancer	CCLE	SRTPLLSMS	DEG_APCC_DBOX_1	0.1389
p.P1471S	MZ7-mel	skin	COSMIC	SRTPLLSMS	DEG_APCC_DBOX_1	0.1389
p.T1454I	DO229213	THCA	ICGC	SRTPLLSMS	DEG_APCC_DBOX_1	0.7222
p.L1460V	SIDM01765	Osteosarcoma	GDSC	SRTPLLSMS	DEG_APCC_DBOX_1	0.6765
p.L1460V	ACH-000529	Non-Cancerous	CCLE	SRTPLLSMS	DEG_APCC_DBOX_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_APCC_DBOX_1	1456:1464	SRTPLLSMS	APC,CDC20,FZR1	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons