DegronMD

Uniprot ID: Q02363

Source protein: DNA-binding protein inhibitor ID-2

Source gene: ID2

Class: DEG_APCC_DBOX_1

Location: 99:107

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9972

ASA_SCORE: 76.6222

COIL: 0.83

CONS_SCORE: 0.4685

DSS_SCORE: 0.5074

HELIX: 0.1097

FCONS_SCORE: 1.1294

RIG_SCORE: 0.723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H89R	TCGA-BA-A4II	HNSC	TCGA	SRTPLTTLN	DEG_APCC_DBOX_1	0.0556
p.H89R	DO52030	HNSC	ICGC	SRTPLTTLN	DEG_APCC_DBOX_1	0.0556
p.S114P	DO42256	UCEC	ICGC	SRTPLTTLN	DEG_APCC_DBOX_1	0.1389
p.L103R	SIDM00638	Cervical Carcinoma	GDSC	SRTPLTTLN	DEG_APCC_DBOX_1	0.8428
p.L103R	ACH-001360	Cervical Cancer	CCLE	SRTPLTTLN	DEG_APCC_DBOX_1	0.8428
p.L103R	MS751	cervix	COSMIC	SRTPLTTLN	DEG_APCC_DBOX_1	0.8428
p.Q95K	ACH-001184	Sarcoma	CCLE	SRTPLTTLN	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02363	DNA-binding protein inhibitor ID-2	DEG_APCC_DBOX_1	99:107	SRTPLTTLN	APC,CDC20,FZR1	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons