DegronMD

Uniprot ID: Q9BYW2

Source protein: Histone-lysine N-methyltransferase SETD2

Source gene: SETD2

Class: DEG_APCC_DBOX_1

Location: 135:143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9725

ASA_SCORE: 91.3222

COIL: 0.6923

CONS_SCORE: 0.2953

DSS_SCORE: 0.4887

HELIX: 0.1394

FCONS_SCORE: 1.0133

RIG_SCORE: 0.7188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S130Y	TCGA-EI-6881	READ	TCGA	SRVELGKIH	DEG_APCC_DBOX_1	0.6389
p.S130Y	DO37098	READ	ICGC	SRVELGKIH	DEG_APCC_DBOX_1	0.6389
p.H147N	DO229025	LICA	ICGC	SRVELGKIH	DEG_APCC_DBOX_1	0.2222
p.P132S	DO220873	MELA	ICGC	SRVELGKIH	DEG_APCC_DBOX_1	0.25
p.K141R	DO32980	PACA	ICGC	SRVELGKIH	DEG_APCC_DBOX_1	0.6126
p.E138D	DO229491	SKCA	ICGC	SRVELGKIH	DEG_APCC_DBOX_1	0.5647
p.K145N	SIDM01171	Glioblastoma	GDSC	SRVELGKIH	DEG_APCC_DBOX_1	0.2778
p.K145N	ACH-000571	Brain Cancer	CCLE	SRVELGKIH	DEG_APCC_DBOX_1	0.2778
p.K145N	T98G	central_nervous_system	COSMIC	SRVELGKIH	DEG_APCC_DBOX_1	0.2778
p.G140D	SIDM00683	Prostate Carcinoma	GDSC	SRVELGKIH	DEG_APCC_DBOX_1	0.6087
p.G140D	ACH-000977	lymph_node	CCLE	SRVELGKIH	DEG_APCC_DBOX_1	0.6087
p.G140D	LNCaP-Clone-FGC	prostate	COSMIC	SRVELGKIH	DEG_APCC_DBOX_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_APCC_DBOX_1	135:143	SRVELGKIH	APC,CDC20,FZR1	0.9725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons