DegronMD

Uniprot ID: Q53HC9

Source protein: EARP and GARP complex-interacting protein 1

Source gene: EIPR1

Class: DEG_APCC_DBOX_1

Location: 295:303

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7238

ASA_SCORE: 25.4222

COIL: 0.3808

CONS_SCORE: 0.5126

DSS_SCORE: 0.3182

HELIX: 0.0184

FCONS_SCORE: 0.8826

RIG_SCORE: 0.7756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P291T	SIDM00458	Acute Myeloid Leukemia	GDSC	SRVILSNMV	DEG_APCC_DBOX_1	0.2222
p.P291T	SIDM00983	Bladder Carcinoma	GDSC	SRVILSNMV	DEG_APCC_DBOX_1	0.2222
p.P291T	647-V	urinary_tract	COSMIC	SRVILSNMV	DEG_APCC_DBOX_1	0.2222
p.P291T	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	SRVILSNMV	DEG_APCC_DBOX_1	0.2222
p.E308K	COLO-741	large_intestine	COSMIC	SRVILSNMV	DEG_APCC_DBOX_1	0.1944
p.G311S	PANC-08-13	pancreas	COSMIC	SRVILSNMV	DEG_APCC_DBOX_1	0.1111
p.G311S	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	SRVILSNMV	DEG_APCC_DBOX_1	0.1111
p.F310S	SNU-1040	large_intestine	COSMIC	SRVILSNMV	DEG_APCC_DBOX_1	0.1389
p.I305T	Ca9-22	upper_aerodigestive_tract	COSMIC	SRVILSNMV	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53HC9	EARP and GARP complex-interacting protein 1	DEG_APCC_DBOX_1	295:303	SRVILSNMV	APC,CDC20,FZR1	0.7238	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons