DegronMD

Uniprot ID: A8K8P3

Source protein: Protein SFI1 homolog

Source gene: SFI1

Class: DEG_COP1_1

Location: 1116:1124

E3 ligase: COP1

DEGRON score: 0.9791

ASA_SCORE: 75.8222

COIL: 0.8882

CONS_SCORE: 0.2994

DSS_SCORE: 0.5795

HELIX: 0.0831

FCONS_SCORE: 1.0461

RIG_SCORE: 0.6394

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1122T	TCGA-DF-A2KN	UCEC	TCGA	SSLASVPDP	DEG_COP1_1	0.7031
p.G1130W	TCGA-EE-A2ME	SKCM	TCGA	SSLASVPDP	DEG_COP1_1	0.1667
p.E1125K	DO51625	CESC	ICGC	SSLASVPDP	DEG_COP1_1	0.3056
p.Q1130R	DO233281	GACA	ICGC	SSLASVPDP	DEG_COP1_1	0.1667
p.V1127E	DO14830	HNSC	ICGC	SSLASVPDP	DEG_COP1_1	0.25
p.E1128D	DO50840	LIRI	ICGC	SSLASVPDP	DEG_COP1_1	0.2222
p.E1119K	ACH-001525	Cervical Cancer	CCLE	SSLASVPDP	DEG_COP1_1	0.7022
p.E1119K	HT-3	cervix	COSMIC	SSLASVPDP	DEG_COP1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8K8P3	Protein SFI1 homolog	DEG_COP1_1	1116:1124	SSLASVPDP	COP1	0.9791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons