DegronMD

Uniprot ID: Q96S59

Source protein: Ran-binding protein 9

Source gene: RANBP9

Class: DEG_COP1_1

Location: 534:542

E3 ligase: COP1

DEGRON score: 0.9729

ASA_SCORE: 73.8889

COIL: 0.7292

CONS_SCORE: 0.5763

DSS_SCORE: 0.5269

HELIX: 0.2158

FCONS_SCORE: 1.0088

RIG_SCORE: 0.6854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C527Y	TCGA-BR-4184	STAD	TCGA	SSNLNVPEL	DEG_COP1_1	0.1389
p.C527Y	DO38328	STAD	ICGC	SSNLNVPEL	DEG_COP1_1	0.1389
p.S544N	TCGA-C5-A8YQ	CESC	TCGA	SSNLNVPEL	DEG_COP1_1	0.2778
p.S544N	DO49906	CESC	ICGC	SSNLNVPEL	DEG_COP1_1	0.2778
p.Q533K	TCGA-D3-A2JC	SKCM	TCGA	SSNLNVPEL	DEG_COP1_1	0.3056
p.Q533K	DO47578	SKCM	ICGC	SSNLNVPEL	DEG_COP1_1	0.3056
p.S548L	DO7000	CLLE	ICGC	SSNLNVPEL	DEG_COP1_1	0.1667
p.I545V	DO231549	LINC	ICGC	SSNLNVPEL	DEG_COP1_1	0.25
p.M547T	SIDM01117	Small Cell Lung Carcinoma	GDSC	SSNLNVPEL	DEG_COP1_1	0.1944
p.M547T	SIDM00808	Burkitt's Lymphoma	GDSC	SSNLNVPEL	DEG_COP1_1	0.1944
p.M547T	SIDM01254	Burkitt's Lymphoma	GDSC	SSNLNVPEL	DEG_COP1_1	0.1944
p.K531T	SIDM00118	Colorectal Carcinoma	GDSC	SSNLNVPEL	DEG_COP1_1	0.6944
p.K531T	ACH-001081	Colon/Colorectal Cancer	CCLE	SSNLNVPEL	DEG_COP1_1	0.6944
p.K531T	HCC2998	large_intestine	COSMIC	SSNLNVPEL	DEG_COP1_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96S59	Ran-binding protein 9	DEG_COP1_1	534:542	SSNLNVPEL	COP1	0.9729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons