DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SSTSTSRPVPTA
Uniprot ID:
Q96MY1
Source protein:
Nucleolar protein 4-like
Source gene:
NOL4L
Class:
DEG_COP1_1
Location:
386:397
E3 ligase:
COP1
DEGRON score:
0.9778
ASA_SCORE:
87.975
COIL:
0.9458
CONS_SCORE:
0.3601
DSS_SCORE:
0.6983
HELIX:
0.0364
FCONS_SCORE:
0.8008
RIG_SCORE:
0.63
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T402A
SNU-1040
large_intestine
COSMIC
SSTSTSRPVPTA
DEG_COP1_1
0.6389
Drug responses associated with NOL4L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SSTSTSRPVPTA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96MY1
Nucleolar protein 4-like
DEG_COP1_1
386:397
SSTSTSRPVPTA
COP1
0.9778
More...