DegronMD

Uniprot ID: Q86U44

Source protein: N6-adenosine-methyltransferase catalytic subunit

Source gene: METTL3

Class: DEG_COP1_1

Location: 64:72

E3 ligase: COP1

DEGRON score: 0.9937

ASA_SCORE: 78.8222

COIL: 0.9138

CONS_SCORE: 0.2877

DSS_SCORE: 0.6705

HELIX: 0.0496

FCONS_SCORE: 0.8913

RIG_SCORE: 0.6478

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S64G	TCGA-AP-A1DK	UCEC	TCGA	STASAVPEL	DEG_COP1_1	0.6993
p.S64G	DO42033	UCEC	ICGC	STASAVPEL	DEG_COP1_1	0.6993
p.S58F	TCGA-MP-A4T4	LUAD	TCGA	STASAVPEL	DEG_COP1_1	0.1667
p.S58F	DO45357	LUAD	ICGC	STASAVPEL	DEG_COP1_1	0.1667
p.E71D	DO222960	BTCA	ICGC	STASAVPEL	DEG_COP1_1	0.5647
p.K80Q	SIDM01490	Small Cell Lung Carcinoma	GDSC	STASAVPEL	DEG_COP1_1	0.2222
p.K80Q	ACH-000382	Lung Cancer	CCLE	STASAVPEL	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86U44	N6-adenosine-methyltransferase catalytic subunit	DEG_COP1_1	64:72	STASAVPEL	COP1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons