DegronMD

Uniprot ID: Q9NZI6

Source protein: Transcription factor CP2-like protein 1

Source gene: TFCP2L1

Class: DEG_SCF_SKP2-CKS1_1

Location: 173:180

E3 ligase: SKP2,CSK1

DEGRON score: 0.6545

ASA_SCORE: 63.475

COIL: 0.5809

CONS_SCORE: 0.8606

DSS_SCORE: 0.3504

HELIX: 0.0567

FCONS_SCORE: 1.1588

RIG_SCORE: 0.7525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G182E	TCGA-SH-A9CT	MESO	TCGA	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.2778
p.G183S	DO230343	COCA	ICGC	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.25
p.R190Q	DO233898	GACA	ICGC	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.0556
p.H181N	DO229022	LICA	ICGC	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.3056
p.G182R	DO231813	LINC	ICGC	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K180R	SIDM01951	Colorectal Carcinoma	GDSC	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.7237
p.P188H	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P188H	SU-DHL-8	NS	COSMIC	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.1111
p.G186E	SIDM00304	Ovarian Carcinoma	GDSC	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.1667
p.G186E	ACH-002146	Ovarian Cancer	CCLE	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.1667
p.G186E	JHOS-3	ovary	COSMIC	STEFTPRK	DEG_SCF_SKP2-CKS1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZI6	Transcription factor CP2-like protein 1	DEG_SCF_SKP2-CKS1_1	173:180	STEFTPRK	SKP2,CSK1	0.6545	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons