DegronMD

Uniprot ID: O94885

Source protein: SAM and SH3 domain-containing protein 1

Source gene: SASH1

Class: DEG_COP1_1

Location: 1204:1212

E3 ligase: COP1

DEGRON score: 0.5777

ASA_SCORE: 50.6

COIL: 0.5298

CONS_SCORE: 0.5917

DSS_SCORE: 0.1974

HELIX: 0.4632

FCONS_SCORE: 1.2228

RIG_SCORE: 0.748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1204T	TCGA-AY-4071	COAD	TCGA	STLSQVPSL	DEG_COP1_1	0.6005
p.S1204T	DO9146	COAD	ICGC	STLSQVPSL	DEG_COP1_1	0.6005
p.Q1218K	TCGA-UY-A9PF	BLCA	TCGA	STLSQVPSL	DEG_COP1_1	0.1667
p.Q1218K	DO219044	BLCA	ICGC	STLSQVPSL	DEG_COP1_1	0.1667
p.S1199F	TCGA-XF-A8HE	BLCA	TCGA	STLSQVPSL	DEG_COP1_1	0.1944
p.S1199F	DO49797	BLCA	ICGC	STLSQVPSL	DEG_COP1_1	0.1944
p.I1222T	TCGA-XF-A8HG	BLCA	TCGA	STLSQVPSL	DEG_COP1_1	0.0556
p.I1222T	DO49802	BLCA	ICGC	STLSQVPSL	DEG_COP1_1	0.0556
p.A1201S	DO229034	LICA	ICGC	STLSQVPSL	DEG_COP1_1	0.25
p.Y1194C	SIDM02050	Colorectal Carcinoma	GDSC	STLSQVPSL	DEG_COP1_1	0.0556
p.A1195T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	STLSQVPSL	DEG_COP1_1	0.0833
p.F1203C	SIDM00118	Colorectal Carcinoma	GDSC	STLSQVPSL	DEG_COP1_1	0.3056
p.F1203C	ACH-001081	Colon/Colorectal Cancer	CCLE	STLSQVPSL	DEG_COP1_1	0.3056
p.F1203C	HCC2998	large_intestine	COSMIC	STLSQVPSL	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94885	SAM and SH3 domain-containing protein 1	DEG_COP1_1	1204:1212	STLSQVPSL	COP1	0.5777	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons