DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SVDLRVPSP
Uniprot ID:
P84996
Source protein:
Protein ALEX
Source gene:
GNAS
Class:
DEG_COP1_1
Location:
558:566
E3 ligase:
COP1
DEGRON score:
0.9724
ASA_SCORE:
87.7667
COIL:
0.9338
CONS_SCORE:
0.6923
DSS_SCORE:
0.5125
HELIX:
0.0247
FCONS_SCORE:
0.9742
RIG_SCORE:
0.7129
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GNAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SVDLRVPSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P84996
Protein ALEX
DEG_COP1_1
558:566
SVDLRVPSP
COP1
0.9724
More...