DegronMD

Uniprot ID: Q8IXS8

Source protein: Protein FAM126B

Source gene: FAM126B

Class: DEG_SCF_SKP2-CKS1_1

Location: 419:426

E3 ligase: SKP2,CSK1

DEGRON score: 0.9864

ASA_SCORE: 88.275

COIL: 0.7288

CONS_SCORE: 0.3654

DSS_SCORE: 0.4196

HELIX: 0.2051

FCONS_SCORE: 1.2083

RIG_SCORE: 0.7696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L422V	TCGA-3L-AA1B	COAD	TCGA	SVELTPMK	DEG_SCF_SKP2-CKS1_1	0.5654
p.L422V	DO50089	COAD	ICGC	SVELTPMK	DEG_SCF_SKP2-CKS1_1	0.5654
p.E421Q	DO233110	GACA	ICGC	SVELTPMK	DEG_SCF_SKP2-CKS1_1	0.6744
p.P412T	DO229028	LICA	ICGC	SVELTPMK	DEG_SCF_SKP2-CKS1_1	0.1389
p.V420D	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	SVELTPMK	DEG_SCF_SKP2-CKS1_1	0.6674
p.V420D	ACH-000912	Lung Cancer	CCLE	SVELTPMK	DEG_SCF_SKP2-CKS1_1	0.6674

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXS8	Protein FAM126B	DEG_SCF_SKP2-CKS1_1	419:426	SVELTPMK	SKP2,CSK1	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons